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Question:
I have been taking 75mg. of Effexor once a day to fight panic attacks. Originally I was taking Paxil, but I had an almost complete loss of sensation in my penis and during ejaculation. The Effexor is not much better. As a result of loss of sensation, I lose my erections. Is there anything I can take to counter these side effects?

Answer:
by Carolyn Gerdes:
(05/15/2004)
:Effexor (venlafaxine HCl) is medication that is used most commonly for the treatment of depression. However, many physicians also prescribe it for the treatment of other conditions such as panic attacks and obsessive compulsive disorders. Effexor is a structurally unique compound that is not related to other available antidepressant agents such as the tricyclics or heterocyclics. In the brain, Effexor inhibits the uptake of both serotonin and norepinephrine. Prozac, Paxil, and Zoloft are also commonly prescribed for the same conditions that Effexor is used for. Prozac, Paxil, and Zoloft function in the brain as selective serotonin reuptake inhibitors (SSRIšs). The SSRIšs are notorious for causing disturbances in sexual function in both males and females. Unfortunately, erectile disturbances, ejaculatory problems and anorgasmia are also some of the most frequent side effects associated with Effexor. If a patient is experiencing disturbances with sexual functioning a physician may opt to switch the person to a different medication. In your case since a switch in medication has not been beneficial, you may want to speak with your physician about lowing your daily dose. In many cases reducing the dose of a medication may alleviate some of the side effects but not interfere with its therapeutic effects. With many medications, side effects become less pronounced over time. However, waiting to see if the side effects decrease requires time and can also provoke undo anxiety. Other ways of addressing the issue of side effects include the use of drug holidays. With drug holidays an individual refrains from taking their medication for a day or two before they plan on engaging in sexual activities. However, the use of drug holidays does not allow for spontaneity and should only be attempted after consulting with the physician who prescribed the medication. In recent years there have also been many herbal remedies appearing in drug stores and health food stores that promise to restore libido and/or lost functions. One of the most researched compounds that has been long used to enhance sexual functions is yohimbine. Yohimbine is derived from the bark of an African tree. It was originally approved by the Food and Drug Administration of the United States as a treatment for high blood pressure. However, it has a long history of also being used for the treatment of male erectile disorders. The scientific literature available on the effects of yohimbine on erectile dysfunction is mixed. A prescription strength form of yohimbine is sold under the trade name of Yocan and is often prescribed for erectile dysfunction. The normal dose is 1 tablet three times a day. Yohimbine is something that you may want to speak to your doctor about. It is however important to keep in mind that yohimbine produces different results in different people and therefore it may not solve your problem. Side effects may also occur with the use of yohimbine. Commonly reported side effects include nervousness, dizziness, and insomnia. These side effects may also been intensified if yohimbine is used in combination with coffee, tea, chocolate or ginseng.

Reviewed by Sexual Health Editorial Team

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